Development of a fluorescein analogue, TokyoMagenta, as a novel scaffold for fluorescence probes in red region
- 28 February 2011
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- Vol. 47 (14), 4162-4164
- https://doi.org/10.1039/c1cc00078k
Abstract
We present a design strategy for fluorescence probes with a high off/on activation ratio in the red wavelength region, based on a novel fluorescein analogue in which the O atom at the 10 position of the xanthene chromophore is replaced with a Si atom. To demonstrate the usefulness of this strategy, we designed and synthesized a red-fluorescent probe for β-galactosidase, and showed that it works in live HEK293 cells.Keywords
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