Threats to the Mind
- 1 March 2009
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Stroke
- Vol. 40 (3_suppl_1), S40-4
- https://doi.org/10.1161/strokeaha.108.533638
Abstract
Aging, Alzheimer disease, and hypertension, major determinants of cognitive dysfunction, are associated with profound alterations in the structure and function of cerebral blood vessels. These vascular alterations may impair the delivery of energy substrates and nutrients to the active brain, and impede the clearance of potentially toxic metabolic byproducts. Reactive oxygen species derived form the enzyme NADPH oxidase are key pathogenic effectors of the cerebrovascular dysregulation. The resulting alterations in the homeostasis of the cerebral microenvironment may lead to cellular dysfunction and death and to cognitive impairment. The prominent role that cerebrovascular oxidative stress plays in conditions associated with cognitive impairment suggests new therapeutic opportunities to counteract and, possibly, reverse the devastating effects of cerebrovascular dysfunction on the brain.This publication has 29 references indexed in Scilit:
- Hypertension and Cerebrovascular DysfunctionCell Metabolism, 2008
- The Hemo-Neural Hypothesis: On The Role of Blood Flow in Information ProcessingJournal of Neurophysiology, 2008
- Endocytosis Is Required for Synaptic Activity-Dependent Release of Amyloid-β In VivoNeuron, 2008
- Nox2-derived radicals contribute to neurovascular and behavioral dysfunction in mice overexpressing the amyloid precursor proteinProceedings of the National Academy of Sciences of the United States of America, 2008
- Glial regulation of the cerebral microvasculatureNature Neuroscience, 2007
- Nox enzymes, ROS, and chronic disease: An example of antagonistic pleiotropyFree Radical Biology & Medicine, 2007
- Nox2-Derived Reactive Oxygen Species Mediate Neurovascular Dysregulation in the Aging Mouse BrainJournal of Cerebral Blood Flow & Metabolism, 2007
- White Matter Lesions in an Unselected Cohort of the ElderlyStroke, 2006
- Reactive oxygen species: influence on cerebral vascular toneJournal of Applied Physiology, 2006
- Biochemical mechanisms for translational regulation in synaptic plasticityNature Reviews Neuroscience, 2004