Comment on “ Drosophila Dosage Compensation Involves Enhanced Pol II Recruitment to Male X-Linked Promoters”
- 19 April 2013
- journal article
- editorial
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 340 (6130), 273
- https://doi.org/10.1126/science.1231895
Abstract
Conrad et al . (Reports, 10 August 2012, p. 742) reported that Drosophila dosage compensation might largely be due to increased recruitment of RNA polymerase II to promoters. A reassessment of the numerical operations revealed that the authors’ calculations are severely confounded by an inappropriate numerical procedure. A rectified analysis strongly suggests that the authors’ conclusions are not supported by their data.Keywords
This publication has 3 references indexed in Scilit:
- Drosophila Dosage Compensation Involves Enhanced Pol II Recruitment to Male X-Linked PromotersScience, 2012
- Transcription modulation chromosome-wide: universal features and principles of dosage compensation in worms and fliesCurrent Opinion in Genetics & Development, 2011
- X chromosome dosage compensation via enhanced transcriptional elongation in DrosophilaNature, 2011