Epoxytwinol A, a novel unique angiogenesis inhibitor with C2 symmetry, produced by a fungus
- 15 March 2005
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 20,p. 2575-2577
- https://doi.org/10.1039/b501392e
Abstract
We isolated a novel unique pentaketide dimer designated as epoxytwinol A from the fermentation broth of a fungus. The structure of epoxytwinol A was determined to have a new carbon skeleton with C2 symmetry by elucidation of spectroscopic evidence. Epoxytwinol A inhibited endothelial cell migration stimulated by vascular endothelial growth factor (ED100 = 2.6 µM).Keywords
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