Shear Stress Biology of the Endothelium
- 1 December 2005
- journal article
- review article
- Published by Springer Science and Business Media LLC in Annals of Biomedical Engineering
- Vol. 33 (12), 1714-1718
- https://doi.org/10.1007/s10439-005-8774-0
Abstract
The relationships between blood flow, mechanotransduction, and the localization of arterial lesions can now be advanced by the incorporation of new technologies and the refinement of existing methods in imaging modalities, computational modeling, fluid dynamics, and high throughput genomics and proteomics. When combined with traditional cell and molecular technologies, a powerful palette of investigative approaches is available to address shear stress biology of the endothelium at levels extending from nanoscale subcellular detailed mechanistic responses through to higher organizational levels of regional endothelial phenotypes and heterogeneous vascular bedKeywords
This publication has 52 references indexed in Scilit:
- Endothelial Cell Glycocalyx Modulates Immobilization of Leukocytes at the Endothelial SurfaceArteriosclerosis, Thrombosis, and Vascular Biology, 2003
- Differential structural adaptation to haemodynamics along single rat cremaster arteriolesThe Journal of Physiology, 2003
- Balance between myogenic, flow-dependent, and metabolic flow control in coronary arterial tree: a model studyAmerican Journal of Physiology-Heart and Circulatory Physiology, 2002
- Gene expression profiling of human aortic endothelial cells exposed to disturbed flow and steady laminar flowPhysiological Genomics, 2002
- Minimum information about a microarray experiment (MIAME)—toward standards for microarray dataNature Genetics, 2001
- DNA microarray analysis of gene expression in endothelial cells in response to 24-h shear stressPhysiological Genomics, 2001
- The adhesion receptor CD44 promotes atherosclerosis by mediating inflammatory cell recruitment and vascular cell activationJCI Insight, 2001
- Flow-mediated endothelial mechanotransductionPhysiological Reviews, 1995
- Turbulent fluid shear stress induces vascular endothelial cell turnover in vitro.Proceedings of the National Academy of Sciences of the United States of America, 1986
- Arterial Wall Shear and Distribution of Early Atheroma in ManNature, 1969