Plasma levels of natriuretic peptides in relation to doxorubicin‐induced cardiotoxicity and cardiac function in children with cancer
- 16 July 2001
- journal article
- research article
- Published by Wiley in Medical and Pediatric Oncology
- Vol. 37 (1), 4-9
- https://doi.org/10.1002/mpo.1155
Abstract
Background Anthracyclines are effective anticancer drugs for childhood cancer with dose-limiting cardiotoxicity. Children who have received anthracyclines thus need periodical cardiac evaluation. The plasma levels of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) have been shown to increase in proportion to severity of cardiac dysfunction. We examined whether plasma levels of ANP and BNP, in addition to echocardiographic evaluation, can be used as specific markers for doxorubicin-induced cardiotoxic effects in children. Procedure Consecutively, 34 patients (18 boys and 16 girls) who had previously received doxorubicin-containing chemotherapy were enrolled in this study. Plasma ANP and BNP were assayed simultaneously at the time of first cardiac function evaluation by echocardiography. Results Of the 34 patients, 8 (23.5%) had left ventricular dysfunction as assessed by echocardiography. Both ANP and BNP plasma levels in these patients were significantly elevated in comparison with healthy controls (P < 0.01) or patients with normal cardiac function (P < 0.05). It should be also noted that ANP and BNP levels were correlated significantly with cardiac systolic function, but not with diastolic function. Conclusions These results suggest that plasma ANP and BNP levels could be markers for doxorubicin-induced cardiotoxicity in children. Measurement of natriuretic peptide levels during treatment may allow earlier-identification of individuals at risk for severe cardiac damage. Med. Pediatr. Oncol. 37:4–9, 2001.This publication has 19 references indexed in Scilit:
- Review of Tests for Monitoring Doxorubicin-lnduced CardiomyopathyOncology, 1996
- Cardiac Failure and Dysrhythmias 6–19 Years After Anthracycline Therapy: A Series of 15 PatientsMedical and Pediatric Oncology, 1995
- Left ventricular diastolic function after anthracycline chemotherapy in childhood: relation with systolic function, symptoms, and pathophysiology.Heart, 1995
- Detection of left ventricular dysfunction after acute myocardial infarction: comparison of clinical, echocardiographic, and neurohormonal methods.Heart, 1994
- Atrial natriuretic peptide as a marker for doxorubicin-induced cardiotoxic effectsCancer, 1992
- Brain natriuretic peptide as a novel cardiac hormone in humans. Evidence for an exquisite dual natriuretic peptide system, atrial natriuretic peptide and brain natriuretic peptide.JCI Insight, 1991
- Normal values for noninvasive estimation of left ventricular contractile state and afterload in childrenThe American Journal of Cardiology, 1990
- Assessment of Diastolic Function of the Heart: Background and Current Applications of Doppler Echocardiography. Part II. Clinical StudiesMayo Clinic Proceedings, 1989
- Alterations in left ventricular diastolic function with doxorubicin therapyJournal of the American College of Cardiology, 1987
- Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements.Cell Metabolism, 1978