Changes in Aspects Such as the Collagenous Fiber Density and Foam Cell Size of Atherosclerotic Lesions Composed of Foam Cells, Smooth Muscle Cells and Fibrous Components in Rabbits Caused by All-cis-5, 8, 11, 14, 17-icosapentaenoic Acid.
- 1 January 2002
- journal article
- Published by Japan Atherosclerosis Society in Journal of Atherosclerosis and Thrombosis
- Vol. 9 (4), 170-177
- https://doi.org/10.5551/jat.9.170
Abstract
Atherosclerotic plaques composed of foamed macrophages, smooth muscle cells and fibrous components in the twice-injured carotid artery from 1% cholesterol diet (HCD)-fed rabbits were prepared and the effects of all-cis-5, 8, 11, 14, 17-icosapentaenoic acid (EPA) on the histopathological properties of atherosclerotic lesions were examined. During the test period, there was no significant difference between the control and the EPA-treated groups in serum lipid levels. In the control group, atherosclerotic lesions were composed of foamed macrophages, smooth muscle cells and fibrous components. Some of the lesions had a large core of foamed macrophages covered with a thin cap of smooth muscle cells and fibrous components, and were morphologically similar to human vulnerable plaques. The classification of plaques, composing atherosclerotic lesions based on collagenous fiber density and foam cell size indicated that over 70% of plaques in the control group were poor in collagenous fiber, while about 20% of plaques contained only large foam cells. In contrast to the control group, over 70% of plaques in the EPA-treated group were rich in collagenous fiber and only 3% consisted of large foam cells. These results suggest that EPA changes certain aspects of pre-existing atherosclerotic lesions.Keywords
This publication has 25 references indexed in Scilit:
- Atherosclerotic Plaques Composed of a Large Core of Foam Cells Covered with Thin Fibrous Caps in Twice-injured Carotid Arterial Specimens Obtained From High Cholesterol Diet-Fed RabbitsJournal of Atherosclerosis and Thrombosis, 2000
- Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trialThe Lancet, 1999
- Fish Consumption and the 30-Year Risk of Fatal Myocardial InfarctionNew England Journal of Medicine, 1997
- Randomized, Double-Blind, Placebo-Controlled Trial of Fish Oil and Mustard Oil in Patients with Suspected Acute Myocardial Infarction: The Indian Experiment of Infarct Survival—4Cardiovascular Drugs and Therapy, 1997
- Inhibitory Effect of Fish Oil N-3 Polyunsaturated Fatty Acids on the Expression of Endothelial Cell Adhesion MoleculesBiochemical and Biophysical Research Communications, 1996
- N‐3 but not N‐6 fatty acids reduce the expression of the combined adhesion and scavenger receptor CD36 in human monocytic cellsCell Biochemistry and Function, 1995
- Molecular Bases of the Acute Coronary SyndromesCirculation, 1995
- Effects of Highly Purified Ethyl All-cis-5,8,11,14,17-icosapentaenoate(EPA-E) on Rabbit Platelets.Biological & Pharmaceutical Bulletin, 1993
- Epidemiological Evidence of Relationships between Dietary Polyunsaturated Fatty Acids and Mortality in the Multiple Risk Factor Intervention TrialExperimental Biology and Medicine, 1992
- Eicosapentaenoic acid as a modulator of inflammationBiochemical Pharmacology, 1986