A systematic review of antibody mediated immunity to coronaviruses: kinetics, correlates of protection, and association with severity
Top Cited Papers
Open Access
- 17 September 2020
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Communications
- Vol. 11 (1), 1-16
- https://doi.org/10.1038/s41467-020-18450-4
Abstract
Many public health responses and modeled scenarios for COVID-19 outbreaks caused by SARS-CoV-2 assume that infection results in an immune response that protects individuals from future infections or illness for some amount of time. The presence or absence of protective immunity due to infection or vaccination (when available) will affect future transmission and illness severity. Here, we review the scientific literature on antibody immunity to coronaviruses, including SARS-CoV-2 as well as the related SARS-CoV, MERS-CoV and endemic human coronaviruses (HCoVs). We reviewed 2,452 abstracts and identified 491 manuscripts relevant to 5 areas of focus: 1) antibody kinetics, 2) correlates of protection, 3) immunopathogenesis, 4) antigenic diversity and cross-reactivity, and 5) population seroprevalence. While further studies of SARS-CoV-2 are necessary to determine immune responses, evidence from other coronaviruses can provide clues and guide future research.Keywords
Funding Information
- John A Watson Faculty Scholar fellowship
- U.S. Department of Health & Human Services | National Institutes of Health (DP2LM013102)
- Burroughs Wellcome Fund (Career Award at the Scientific Interface)
This publication has 154 references indexed in Scilit:
- The dominance of human coronavirus OC43 and NL63 infections in infantsJournal of Clinical Virology, 2012
- The Pediatric Burden of Human Coronaviruses Evaluated for Twenty YearsThe Pediatric Infectious Disease Journal, 2009
- Examination of seroprevalence of coronavirus HKU1 infection with S protein-based ELISA and neutralization assay against viral spike pseudotyped virusJournal of Clinical Virology, 2009
- Long‐Term Care Facilities: A Cornucopia of Viral PathogensJournal of the American Geriatrics Society, 2008
- A line immunoassay utilizing recombinant nucleocapsid proteins for detection of antibodies to human coronavirusesDiagnostic Microbiology and Infectious Disease, 2008
- Seroepidemiology of group I human coronaviruses in childrenJournal of Clinical Virology, 2007
- Use of Antibody Avidity Assays for Diagnosis of Severe Acute Respiratory Syndrome Coronavirus InfectionClinical and Vaccine Immunology, 2007
- Potent cross-reactive neutralization of SARS coronavirus isolates by human monoclonal antibodiesProceedings of the National Academy of Sciences of the United States of America, 2007
- Recombinant Truncated Nucleocapsid Protein as Antigen in a Novel Immunoglobulin M Capture Enzyme-Linked Immunosorbent Assay for Diagnosis of Severe Acute Respiratory Syndrome Coronavirus InfectionClinical and Vaccine Immunology, 2007
- The time course of the immune response to experimental coronavirus infection of manEpidemiology and Infection, 1990