Brain functional impairment in beta‐thalassaemia: the cognitive profile in Italian neurologically asymptomatic adult patients in comparison to the reported literature
- 20 May 2019
- journal article
- research article
- Published by Wiley in British Journal of Haematology
- Vol. 186 (4), 592-607
- https://doi.org/10.1111/bjh.15959
Abstract
Cognitive involvement in beta‐thalassaemia is strikingly controversial and poorly studied in adulthood. This multicentre prospective study investigated 74 adult neurologically‐asymptomatic beta‐thalassaemia patients (mean‐age 34·5 ± 10·3 years; 53 transfusion‐dependent [TDT], 21 non‐transfusion dependent [NTDT]) and 45 healthy volunteers (mean‐age 33·9 ± 10·7 years). Participants underwent testing with Wechsler Adult Intelligence Scale‐Fourth Edition (WAIS‐IV), Brief Psychiatric Rating Scale (BPRS) and multiparametric brain 3T‐magnetic resonance imaging (MRI) for parenchymal, vascular and iron content evaluation. Patients had lower Full‐Scale Intelligence Quotient (FSIQ) than controls (75·5 ± 17·9 vs. 97·4 ± 18·1, P < 0·0001) even after correction for education level. Compared to TDT, NTDT showed a trend of higher FSIQ (P = 0·08) but a similar cognitive profile at WAIS‐subtests. FSIQ correlated with total and indirect bilirubin (P < 0·0001 and P = 0·002, respectively); no correlation was found with splenectomy, intracranial MRI/magnetic resonance‐angiography findings, brain tissue iron content or other disease‐related clinical/laboratory/treatment data. FSIQ did not correlate with BPRS scores, although the latter were higher among patients (28·74 ± 3·1 vs. 27·29 ± 4·8, P = 0·01) mainly because of increased depression and anxiety levels. Occupation rate was higher among controls (84·4% vs. 64·9%, P = 0·004) and correlated with higher FSIQ (P = 0·001) and education level (P = 0·001). In conclusion, Italian adult beta‐thalassaemia patients seem to present a characteristic cognitive profile impairment and an increased rate of psychological disorders with possible profound long‐term socio‐economic consequences.Keywords
This publication has 31 references indexed in Scilit:
- Health-related quality of life in adults with transfusion-independent thalassaemia intermedia compared to regularly transfused thalassaemia major: new insightsEuropean Journal of Haematology, 2011
- Regional specificity of MRI contrast parameter changes in normal ageing revealed by voxel-based quantification (VBQ)NeuroImage, 2011
- Neurocognitive function in patients with β‐thalassemia majorPediatrics International, 2010
- Symptoms of depression and anxiety in patients with thalassemia: Prevalence and correlates in the thalassemia longitudinal cohortAmerican Journal of Hematology, 2010
- Study of Beta-Thalassemia Biomarkers and Their Relationship to Cognition Among ChildrenJournal of Child Neurology, 2010
- A fast diffeomorphic image registration algorithmNeuroImage, 2007
- Cognitive dysfunction in β‐thalassemia minorAmerican Journal of Hematology, 2006
- Detecting psychotic major depression using psychiatric rating scalesJournal of Psychiatric Research, 2006
- Neurophysiologic and intellectual evaluation of beta-thalassemia patientsBrain & Development, 2006
- Quality of Life in Patients with Thalassemia Intermedia Compared to Thalassemia MajorAnnals of the New York Academy of Sciences, 2005