Anti-Gal-C antibodies in GBS subsequent to mycoplasma infection: Evidence of molecular mimicry
- 28 August 2001
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in Neurology
- Vol. 57 (4), 736-738
- https://doi.org/10.1212/wnl.57.4.736
Abstract
The authors previously reported the presence of antibody against galactocerebroside (Gal-C) in sera from patients with Guillain–Barré syndrome subsequent to Mycoplasma pneumoniae infection. Anti-Gal-C antibody activities in these sera were inhibited specifically by the M. pneumoniae reagent. A rabbit anti-Gal-C antibody recognized several glycolipids in M. pneumoniae. These data show that a Gal-C-like structure is present in M. pneumoniae, indicative of molecular mimicry between a major myelin glycolipid, Gal-C, and M. pneumoniae.Keywords
This publication has 10 references indexed in Scilit:
- Encephalomyelitis subsequent to mycoplasma infection with elevated serum anti-Gal C antibodyPediatric Neurology, 1997
- Post-infectious encephalitis with anti-galactocerebroside antibody subsequent to Mycoplasma pneumoniae infectionJournal of the Neurological Sciences, 1996
- Association of anti-GM2 antibodies in Guillain-Barré syndrome with acute cytomegalovirus infectionJournal of Neuroimmunology, 1996
- Anti‐GM1 IgG antibodies and campylobacter bacteria in Guillain‐Barré syndrome: Evidence of molecular mimicryAnnals of Neurology, 1995
- Anti‐gal‐C antibody in autoimmune neuropathies subsequent to mycoplasma infectionMuscle & Nerve, 1995
- Serum anti‐GQ1b IgG antibodies recognize surface epitopes on Campylobacter jejuni from patients with Miller Fisher syndromeAnnals of Neurology, 1995
- Molecular mimicry between GQ1b ganglioside and lipopolysaccharides of Campylobacter jejuni isolated from patients with Fisher's syndromeAnnals of Neurology, 1994
- A bacterium lipopolysaccharide that elicits Guillain-Barré syndrome has a GM1 ganglioside-like structure.The Journal of Experimental Medicine, 1993
- Serum IgG antibody to ganglioside GQ1b is a possible marker of Miller Fisher syndromeAnnals of Neurology, 1992
- Experimental Allergic Neuritis Induced by Sensitization with GalactocerebrosideScience, 1979