Synthesis and application of nanostructured calcium phosphate ceramics for bone regeneration
- 26 September 2012
- journal article
- review article
- Published by Wiley in Journal of Biomedical Materials Research Part B: Applied Biomaterials
- Vol. 100B (8), 2316-2326
- https://doi.org/10.1002/jbm.b.32794
Abstract
In the past two decades, nanotechnology has entered the field of regenerative medicine, resulting in the development of a novel generation of instructive, nanostructured biomaterials that are able to orchestrate cellular behavior by presenting specific morphological and biological cues. Using nanotechnology, materials containing nanosized features (e.g., pores, patterns, textures, grain sizes) can be obtained that exhibit properties that are considerably altered compared with micron‐structured materials. Inspired by the hierarchical nanostructure of bone, the application of nanostructured materials for bone regeneration is gaining increasing interest in the field of biomaterials research. Because crystallographic and chemical studies have shown that synthetic hydroxyapatite closely resembles the inorganic phase found in bone and teeth, synthesis and applications of nanostructured calcium phosphate ceramics have been reviewed. Synthesis techniques for the preparation of calcium phosphate nanoparticles include precipitation, sol–gel, and hydrothermal processes, whereas four main biomedical applications of nanostructured calcium phosphate ceramics in bone regeneration have been addressed in more detail, that is, (1) polymer/calcium phosphate nanocomposites, (2) nanostructured monophasic calcium phosphate bone fillers, (3) nanostructured precursor phases for calcium phosphate cements, and (4) nanostructured calcium phosphate coatings. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2012.Keywords
This publication has 101 references indexed in Scilit:
- Preparation and biocompatibility of nanohybrid scaffolds by in situ homogeneous formation of nano hydroxyapatite from biopolymer polyelectrolyte complex for bone repair applicationsColloids and Surfaces B: Biointerfaces, 2012
- Effects of four types of hydroxyapatite nanoparticles with different nanocrystal morphologies and sizes on apoptosis in rat osteoblastsJournal of Applied Toxicology, 2011
- Posterolateral spinal fusion with nano-hydroxyapatite-collagen/PLA composite and autologous adipose-derived mesenchymal stem cells in a rabbit modelJournal of Tissue Engineering and Regenerative Medicine, 2011
- Electrospun Hydroxyapatite-Functionalized PLLA Scaffold: Potential Applications in Sternal Bone HealingAnnals of Biomedical Engineering, 2011
- Co-loading of bisphosphonates and antibiotics to a biomimetic hydroxyapatite coatingBiotechnology Letters, 2011
- In Vitro Osteogenic Differentiation of Human Mesenchymal Stem Cells and In Vivo Bone Formation in Composite Nanofiber MeshesTissue Engineering, Part A, 2008
- The effect of particle design on cellular internalization pathwaysProceedings of the National Academy of Sciences of the United States of America, 2008
- Bone tissue engineering with premineralized silk scaffoldsBone, 2008
- Instant nano-hydroxyapatite: a continuous and rapid hydrothermal synthesisChemical Communications, 2006
- Bacteriostatic properties of biomatrices against common orthopaedic pathogensBiochemical and Biophysical Research Communications, 2004