Analysis of Retinal Layers in Fibromyalgia Patients with Premium Protocol in Optical Tomography Coherence and Quality of Life
- 16 September 2021
- journal article
- research article
- Published by Taylor & Francis Ltd in Current Eye Research
- Vol. 47 (1), 143-153
- https://doi.org/10.1080/02713683.2021.1951301
Abstract
To evaluate the inner retinal layers in fibromyalgia (FM) patients compared to control subjects using posterior pole protocol (PPole) analysis in optical coherence tomography (OCT) and to correlate structural retinal changes with subjective quality of life. Seventy-four eyes of healthy subjects and 55 eyes of those with FM were analyzed. All subjects underwent retinal evaluation using the PPole protocol for Spectralis OCT (Heidelberg Engineering) to obtain measurements of the retinal nerve fiber layer (RNFL) and the ganglion cell layer (GCL) in the macular area. The EuroQol (EQ-5D) questionnaire and Fibromyalgia Impact Questionnaire (FIQ) were performed to analyze health-related quality of life. Additionally, the FM group was divided into three groups depending on the disease phenotype (atypical, depressive and biological). : Patients with FM presented with a reduction of the RNFL thickness compared to controls in 17/64 cells of the PPole area, and a reduction of the GCL thickness in 47/64 cells. Depressive FM phenotype showed the greatest number of cells with significant reduction compared with the control group in both RNFL and GCL layers. A correlation between temporal-inferior cells of the GCL and the EuroQol 5D questionnaire results was observed. Patients with FM present with a reduction of the inner retinal layers in the macular area. This degeneration correlates with disease severity/reduced quality of life in these patients. The PPole protocol for OCT is a non-invasive and fast tool that might help clinicians diagnose and monitor neurodegeneration in FM patients.Keywords
This publication has 30 references indexed in Scilit:
- Fourier-Domain OCT in Multiple Sclerosis Patients: Reproducibility and Ability to Detect Retinal Nerve Fiber Layer AtrophyInvestigative Ophthalmology & Visual Science, 2011
- Gray Matter Volumes of Pain-Related Brain Areas Are Decreased in Fibromyalgia SyndromeThe Journal of Pain, 2011
- Optical coherence tomography helps differentiate neuromyelitis optica and MS optic neuropathiesNeurology, 2009
- Societal and Patient Burden of Fibromyalgia SyndromePharmacoEconomics, 2009
- Evidence of dysfunctional pain inhibition in Fibromyalgia reflected in rACC during provoked painPain, 2009
- The pain of fibromyalgia syndrome is due to muscle hypoperfusion induced by regional vasomotor dysregulationMedical Hypotheses, 2007
- Subgrouping of fibromyalgia patients on the basis of pressure‐pain thresholds and psychological factorsArthritis & Rheumatism, 2003
- The prevalence and characteristics of fibromyalgia in the general populationArthritis & Rheumatism, 1995
- EuroQol - a new facility for the measurement of health-related quality of lifeHealth Policy, 1990
- The american college of rheumatology 1990 criteria for the classification of fibromyalgiaArthritis & Rheumatism, 1990