Efficacy of Anti-Interleukin-1 Receptor Antagonist Anakinra (Kineret®) in a Case of Refractory Sweet’s Syndrome
- 5 April 2011
- journal article
- case report
- Published by S. Karger AG in Dermatology
- Vol. 222 (2), 123-127
- https://doi.org/10.1159/000326112
Abstract
Sweet’s syndrome is a neutrophilic dermatosis characterized by fever, an elevated neutrophil count, and painful erythematous cutaneous lesions. Histopathological analysis reveals a neutrophilic dermal infiltrate. Systemic corticosteroid therapy remains the mainstay of treatment. We report the case of a 66-year-old male patient who had a 5-year history of Sweet’s syndrome refractory to various conventional treatments. Anti-interleukin-1 receptor antagonist anakinra was initiated and this resulted in a dramatic clinical and biological improvement. Anakinra is a promising treatment for neutrophilic dermatoses and sheds light on the interleukin-1/inflammasome pathway as central in the physiopathology of neutrophilic dermatosis.Keywords
This publication has 19 references indexed in Scilit:
- Anakinra for Difficult-to-Treat Neutrophilic Panniculitis: IL-1 Blockade as a Promising Treatment Option for Neutrophil-Mediated Inflammatory Skin DiseaseDermatology, 2010
- Etanercept Treatment in Sweet’s Syndrome with Inflammatory ArthritisThe Journal of Rheumatology, 2009
- A Mutation in the Nlrp3 Gene Causing Inflammasome Hyperactivation Potentiates Th17 Cell-Dominant Immune ResponsesImmunity, 2009
- Sweet Syndrome Presenting as Resistant ConjunctivitisCornea, 2008
- Efficacy of anakinra, an IL1 receptor antagonist, in refractory Sweet syndromeAnnals Of The Rheumatic Diseases, 2008
- Dysphonia Revealing Early SyphilisPublished by Medical Journals Sweden AB ,2008
- Treatment of recurrent Sweet's syndrome with coexisting rheumatoid arthritis with the tumor necrosis factor antagonist etanerceptJournal of the American Academy of Dermatology, 2006
- Refractory Sweet Syndrome With Autoimmune Organizing Pneumonia Treated With Monoclonal Antibodies to Tumor Necrosis FactorJCR: Journal of Clinical Rheumatology, 2004
- An immunohistochemical study of the dermal infiltrate and epidermal staining for interleukin 1 in 12 cases of Sweet's syndromeBritish Journal of Dermatology, 1996
- Is the pathogenesis of Sweet's syndrome mediated by interleukin-I?British Journal of Dermatology, 1987