The bovine T cell receptor alpha/delta locus contains over 400 V genes and encodes V genes without CDR2
Open Access
- 2 July 2009
- journal article
- research article
- Published by Springer Science and Business Media LLC in Immunogenetics
- Vol. 61 (7), 541-549
- https://doi.org/10.1007/s00251-009-0384-9
Abstract
αβ T cells and γδ T cells perform nonoverlapping immune functions. In mammalian species with a high percentage of very diverse γδ T cells, like ruminants and pigs, it is often assumed that αβ T cells are less diverse than γδ T cells. Based on the bovine genome, we have created a map of the bovine TRA/TRD locus and show that, in cattle, in addition to the anticipated >100 TRDV genes, there are also >300 TRAV or TRAV/DV genes. Among the V genes in the TRA/TRD locus, there are several genes that lack a CDR2 and are functionally rearranged and transcribed and, in some cases, have an extended CDR1. The number of bovine V genes is a multiple of the number in mice and humans and may encode T cell receptors that use a novel way of interacting with antigen.Keywords
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