The PROTON study: profiles of blood product transfusion recipients in the Netherlands
- 24 February 2010
- journal article
- Published by Wiley in Vox Sanguinis
- Vol. 99 (1), 54-64
- https://doi.org/10.1111/j.1423-0410.2010.01312.x
Abstract
Transfusion recipient data are needed for correct estimation of cost-effectiveness in terms of recipient outcomes after transfusion. Also, such data are essential for monitoring blood use, estimation of future blood use and benchmarking. A sample of 20 of 93 Dutch hospitals was selected. Datasets containing all blood product transfusions between 1996 and 2006 were extracted from hospital blood bank computer systems, containing transfusion date, blood product type and recipient characteristics such as gender, address, date of birth. The datasets were appended and matched to national hospitalization datasets including primary discharge diagnoses (ICD-9). Using these data, we estimated distributions of blood recipient characteristics in the Netherlands. The dataset contains information on 290,043 patients who received 2,405,012 blood products (1,720,075 RBC, 443,697 FFP, 241,240 PLT) from 1996 to 2006. This is 28% of total blood use in the Netherlands during this period. Comparable diagnosis and age distributions of all hospitalizations indicate included hospitals to be representative, per hospital category, for the Netherlands. Of all red blood cells (RBC), fresh-frozen plasma (FFP) and platelets (PLT), respectively 1.7%, 2.5% and 4.5% were transfused to neonates. Recipients of 65 years or older received 57.6% of RBC, 41.4% of FFP and 29.0% of PLT. Most of the blood products were transfused to patients with diseases of the circulary system (25.1%) or neoplasms (22.0%). Transfusion data from a limited sample of hospitals can be used to estimate national distributions of blood recipient characteristics.Keywords
This publication has 10 references indexed in Scilit:
- Blood transfusion exposure in Denmark and SwedenTransfusion, 2009
- Cost-Effectiveness Analysis: What It Really Means for Transfusion Medicine Decision MakingTransfusion Medicine Reviews, 2009
- Cost‐effectiveness of additional hepatitis B virus nucleic acid testing of individual donations or minipools of six donations in the NetherlandsTransfusion, 2009
- Survival after blood transfusionTransfusion, 2008
- Impact of demographic changes on the blood supply: Mecklenburg‐West Pomerania as a model region for EuropeTransfusion, 2007
- A survey of the demographics of blood useTransfusion Medicine, 2007
- A population‐based binational register for monitoring long‐term outcome and possible disease concordance among blood donors and recipientsVox Sanguinis, 2006
- New donors, new recipients—who gets what in 2003?Transfusion Clinique et Biologique, 2004
- The mantra of blood safety: time for a new tune?Vox Sanguinis, 2004
- On Estimation of a Probability Density Function and ModeThe Annals of Mathematical Statistics, 1962