Current Understanding of Cytomegalovirus Reactivation in Critical Illness
Open Access
- 5 March 2020
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 221 (Supplement), S94-S102
- https://doi.org/10.1093/infdis/jiz638
Abstract
Cytomegalovirus (CMV) reactivation has been described in adults with critical illness caused by diverse etiologies, especially severe sepsis, and observational studies have linked CMV reactivation with worse clinical outcomes in this setting. In this study, we review observational clinical data linking development of CMV reactivation with worse outcomes in patients in the intensive care unit, discuss potential biologically plausible mechanisms for a causal association, and summarize results of initial interventional trials that examined the effects of CMV prevention. These data, taken together, highlight the need for a randomized, placebo-controlled efficacy trial (1) to definitively determine whether prevention of CMV reactivation improves clinical outcomes of patients with critical illness and (2) to define the underlying mechanism(s).Keywords
Funding Information
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (T32 AI118690-02, HHSN272201600016C, HHSN272201100041C, HHSN272201600019C)
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