Association between Helicobacter pylori and liver-to-spleen ratio
- 1 January 2013
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in European Journal of Gastroenterology & Hepatology
- Vol. 25 (1), 107-110
- https://doi.org/10.1097/meg.0b013e3283590c10
Abstract
Helicobacter pylori infection is reported to be associated with some extragastrointestinal manifestations, such as hematological diseases (thrombocytopenia, anemia), obesity, and fatty liver disease. The length or the volume ratio of liver to spleen was suggested to be changed in some hematological and hepatobiliary disorders. We hypothesized that the liver-to-spleen ratio may be affected in H. pylori-positive patients. In this respect, we aimed to evaluate the effect of H. pylori infection on the liver-to-spleen ratio and platelet indices. A total of 174 patients with functional dyspepsia were included in the study. Patients were divided into group 1 (H. pylori-positive gastritis) (n=95) and group 2 (H. pylori negative, control group) (n=79). Liver, spleen length measurement, and liver steatosis scores were performed by ultrasonography by the same physicians who were blinded to the H. pylori results. Blood count values including the platelet count and the mean platelet volume (MPV) were compared between the two groups. BMI was also evaluated as a potential confounding factor for fatty liver. The liver-to-spleen ratio, platelet-to-spleen ratio, MPV-to-spleen ratio, and the MPV-to-liver ratio were significantly lower in the H. pylori-positive group compared with the H. pylori-negative group (P<0.001, <0.001, <0.001, and 0.038, respectively). Fatty liver was significantly more frequent in H. pylori-positive patients. Liver-to-spleen ratio and the MPV-to-spleen ratio are important indices in the pathogenesis of H. pylori-linked liver and spleen manifestations, and thrombocytopenia.Keywords
This publication has 20 references indexed in Scilit:
- Management ofHelicobacter pyloriinfection—the Maastricht IV/ Florence Consensus ReportGut, 2012
- The Association Between Helicobacter pylori Infection and Insulin Resistance: A Systematic ReviewHelicobacter, 2011
- Helicobacter pyloriinfection concomitant with metabolic syndrome further increase risk of colorectal adenomasWorld Journal of Gastroenterology, 2010
- Effect of Helicobacter pylori eradication on platelet count in children with chronic idiopathic thrombocytopenic purpuraHematology, 2009
- The Severity of Ultrasonographic Findings in Nonalcoholic Fatty Liver Disease Reflects the Metabolic Syndrome and Visceral Fat AccumulationThe American Journal of Gastroenterology, 2007
- The Role of Helicobacter pylori in Urticaria and Atopic DermatitisSKINmed: Dermatology for the Clinician, 2006
- High Seroprevalence of Helicobacter pylori in Chronic Bronchitis among Chinese PopulationThe Tohoku Journal of Experimental Medicine, 2006
- Effect of Helicobacter pylori Eradication in Patients with Chronic Idiopathic Thrombocytopenic Purpura-A Randomized Controlled TrialThe American Journal of Gastroenterology, 2005
- Eradication of Helicobacter pylori increases platelet count in patients with idiopathic thrombocytopenic purpura in JapanEuropean Journal of Clinical Investigation, 2005
- Pooling of platelets in the spleen: role in the pathogenesis of "hypersplenic" thrombocytopenia.JCI Insight, 1966