meso-Pyrimidinyl-Substituted A2B-Corroles
- 14 July 2007
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 9 (16), 3165-3168
- https://doi.org/10.1021/ol071226a
Abstract
Meso-Pyrimidinyl-substituted A2B-corroles were synthesized in good yields by condensation of 5-mesityldipyrromethane and 2-substituted 4,6-dichloropyrimidine-5-carbaldehydes. A simple reduction of the amount of Lewis acid (BF3.OEt2) resulted in the formation of A2B-corroles, which was optimized to maximize the corrole yield. Nucleophilic aromatic substitution, Suzuki, and Stille cross-coupling reactions were performed on the Cu-metalated pyrimidinylcorroles to obtain sterically encumbered triarylcorroles, while the substitution pattern at the 2-position of the pyrimidinyl substituent was altered through Liebeskind-Srogl cross-couplings.status: publisheKeywords
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