Synthesis and antimicrobial activities of new pyridinium and benzimidazolium chlorides

Abstract

A novel class of pyridinium and benzimidazolium chloride has been obtained in high yield. The antimicrobial activities of three homologous series of pyridinium and benzimidazolium chlorides against cocci, rods, fungi and bacillus have been measured. The antimicrobial activities of N,N′-bis[3-(1-alkoxymethyl)pyridinium chloride]methylenediamines, 1-undecyloxymethyl-3-(1-benzimidazolmethylamino)pyridinium, 1-undecyloxymethyl- and 1-dodecyloxymethyl-3-[1(benzotriazol-1-yl)methylamino]pyridinium chlorides exhibited strong activity and wide antibacterial spectra similar to the activity of benzalkonium chloride.