A simple assessment of dyspnoea as a prognostic indicator in idiopathic pulmonary fibrosis
Open Access
- 22 April 2010
- journal article
- Published by European Respiratory Society (ERS) in European Respiratory Journal
- Vol. 36 (5), 1067-1072
- https://doi.org/10.1183/09031936.00152609
Abstract
The prognosis in idiopathic pulmonary fibrosis (IPF) is poor. No therapy has been shown to prolong survival. The objective of this study was to examine the prognostic significance of dyspnoea in daily living at baseline in IPF using a simple assessment tool. 93 consecutive patients with IPF, who had undergone evaluation at diagnosis, were included. The level of dyspnoea was assessed using the modified Medical Research Council (MRC) scale. The relationship between data at baseline and survival was examined. A univariate Cox proportional-hazard model showed that forced vital capacity % predicted (hazard ratio (HR) 0.965, 95% CI 0.948–0.982; p = 0.0041), baseline arterial oxygen tension (HR 0.963, 95% CI 0.938–0.989; p = 0.0060) and modified MRC score (HR 2.402, 95% CI 1.495–3.858; p = 0.0003) were significantly predictive of survival. All variables of the 6-min walk test, including walk distance (HR 0.995, 95% CI 0.992–0.998; p = 0.0020), the lowest arterial oxygen saturation measured by pulse oximetry (Sp,O2) (HR 0.944, 95% CI 0.918–0.972; pSp,O2 during the 6-min walk test (HR 0.952, 95% CI 0.924–0.981; p = 0.0014) were the most significant. Dyspnoea in daily living, assessed with the modified MRC scale at baseline, provides additional prognostic information for patients with IPF.Keywords
This publication has 31 references indexed in Scilit:
- The Prognostic Value of Cardiopulmonary Exercise Testing in Idiopathic Pulmonary FibrosisAmerican Journal of Respiratory and Critical Care Medicine, 2009
- The Medical Research Council chronic dyspnea score predicts the survival of patients with idiopathic pulmonary fibrosisRespiratory Medicine, 2008
- Short term improvement in exercise capacity and symptoms following exercise training in interstitial lung diseaseThorax, 2008
- Effects of pulmonary rehabilitation in patients with idiopathic pulmonary fibrosisRespirology, 2007
- Idiopathic Pulmonary FibrosisAmerican Journal of Respiratory and Critical Care Medicine, 2006
- Six-Minute-Walk Distance Predicts Waiting List Survival in Idiopathic Pulmonary FibrosisAmerican Journal of Respiratory and Critical Care Medicine, 2006
- Prevalence and Outcomes of Pulmonary Arterial Hypertension in Advanced Idiopathic Pulmonary FibrosisSocial psychiatry. Sozialpsychiatrie. Psychiatrie sociale, 2006
- The Clinical Course of Patients with Idiopathic Pulmonary FibrosisAnnals of Internal Medicine, 2005
- Health-related quality of life in patients with idiopathic pulmonary fibrosis. What is the main contributing factor?Respiratory Medicine, 2005
- Cryptogenic fibrosing alveolitis: clinical features and their influence on survivalThorax, 1980