Human hypertrophic and keloid scar models: principles, limitations and future challenges from a tissue engineering perspective
Open Access
- 28 May 2014
- journal article
- review article
- Published by Wiley in Experimental Dermatology
- Vol. 23 (6), 382-386
- https://doi.org/10.1111/exd.12419
Abstract
Most cutaneous wounds heal with scar formation. Ideally, an inconspicuous normotrophic scar is formed, but an abnormal scar (hypertrophic scar or keloid) can also develop. A major challenge to scientists and physicians is to prevent adverse scar formation after severe trauma (e.g. burn injury) and understand why some individuals will form adverse scars even after relatively minor injury. Currently, many different models exist to study scar formation, ranging from simple monolayer cell culture to 3D tissue-engineered models even to humanized mouse models. Currently, these high-/medium-throughput test models avoid the main questions referring to why an adverse scar forms instead of a normotrophic scar and what causes a hypertrophic scar to form rather than a keloid scar and also, how is the genetic predisposition of the individual and the immune system involved. This information is essential if we are to identify new drug targets and develop optimal strategies in the future to prevent adverse scar formation. This viewpoint review summarizes the progress on in vitro and animal scar models, stresses the limitations in the current models and identifies the future challenges if scar-free healing is to be achieved in the future.Keywords
This publication has 65 references indexed in Scilit:
- Models of Abnormal ScarringBioMed Research International, 2013
- Chondroitinase injection improves keloid pathology by reorganizing the extracellular matrix with regenerated elastic fibersThe Journal of Dermatology, 2013
- Genomic responses in mouse models poorly mimic human inflammatory diseasesProceedings of the National Academy of Sciences of the United States of America, 2013
- Shear-Activated Nanotherapeutics for Drug Targeting to Obstructed Blood VesselsScience, 2012
- Increased in vitro differentiation of fibrocytes from keloid patients is inhibited by serum amyloid PWound Repair and Regeneration, 2012
- Tumor-Like Stem Cells Derived from Human Keloid Are Governed by the Inflammatory Niche Driven by IL-17/IL-6 AxisPLOS ONE, 2009
- Is There an Ideal Animal Model to Study Hypertrophic Scarring?Journal of Burn Care & Research, 2008
- Use of organotypic coculture to study keloid biologyThe American Journal of Surgery, 2008
- Experimental Keloid Scar Models: A Review of Methodological IssuesJournal of Cutaneous Medicine and Surgery, 2002
- Implants of Hypertrophic Scars and Keloids into the Nude (Athymic) MouseThe Journal of Trauma and Acute Care Surgery, 1989