Selective effects of somatostatin-14, -25 and -28 on in vitro insulin and glucagon secretion
- 1 May 1981
- journal article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 291 (5810), 76-77
- https://doi.org/10.1038/291076a0
Abstract
The widely occurring tetradecapeptide somatostatin (SRIF-14) has been variously implicated as a neurotransmitter, a neurohormone, a cybernin (local regulatory factor) and a hormone. In the first isolation of SRIF-14 from hypothalamic extracts and subsequent extracts of other tissues, peptides of higher molecular weight but with similar activity have been noted. Recently two such peptides have been characterized as the 28-amino acid SRIF-28 (from porcine gastro-intestinal tract and porcine and ovine hypothalamus and the 25-amino acid SRIF-25 (from ovine hypothalamus), each of which consists of an N-terminal extension of SRIF-14. We now report that SRIF-28 and SRIF-25 are more potent than SRIF-14 in the inhibition of insulin release, but that SRIF-14 preferentially inhibits glucagon release. This suggests that SRIF-28 and SRIF-25 are not mere biosynthetic precursors of SRIF-14 and that their differential release may be physiologically important.Keywords
This publication has 22 references indexed in Scilit:
- Effects of somatostatin on the exocrine pancreas and the release of duodenal hormonesMetabolism, 1978
- Somatostatin and the stomach: Exocrine and endocrine aspectsMetabolism, 1978
- Somatostatin in Hypothalamus, Extrahypothalamic Brain, and Peripheral Tissues of the Rat*Endocrinology, 1978
- Immunohistochemical demonstration of somatostatin-containing cells in the human, dog and rat thyroids.The Tohoku Journal of Experimental Medicine, 1977
- Central and peripheral localization of somatostatin. Immunoenzyme immunocytochemical studies.Journal of Histochemistry & Cytochemistry, 1976
- Isolation and structure of somatostatin from porcine hypothalamiBiochemistry, 1976
- Somatostatin: Physiological and Clinical SignificanceAnnual Review of Medicine, 1976
- ‘Barrel rotation’ induced by somatostatin in the non-lesioned ratBrain Research, 1975
- Depressant action of TRH, LH-RH and somatostatin on activity of central neuronesNature, 1975
- Hypothalamic Polypeptide That Inhibits the Secretion of Immunoreactive Pituitary Growth HormoneScience, 1973