Synthetic Associations Are Unlikely to Account for Many Common Disease Genome-Wide Association Signals
Open Access
- 18 January 2011
- journal article
- editorial
- Published by Public Library of Science (PLoS) in PLoS Biology
- Vol. 9 (1), e1000580
- https://doi.org/10.1371/journal.pbio.1000580
Abstract
Synthetic associations have been posited as a possible explanation for missing heritability in complex disease. We show several lines of evidence which suggest that, while possible, these synthetic associations are not common.Keywords
This publication has 30 references indexed in Scilit:
- Twelve type 2 diabetes susceptibility loci identified through large-scale association analysisNature Genetics, 2010
- Interpretation of Association Signals and Identification of Causal Variants from Genome-wide Association StudiesAmerican Journal of Human Genetics, 2010
- Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A regionNature Genetics, 2009
- Finding the missing heritability of complex diseasesNature, 2009
- Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetesNature Genetics, 2009
- Evaluating the Effects of Imputation on the Power, Coverage, and Cost Efficiency of Genome-wide SNP PlatformsAmerican Journal of Human Genetics, 2008
- Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's diseaseNature Genetics, 2008
- Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controlsNature, 2007
- Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibilityNature Genetics, 2007
- Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesisNature Genetics, 2007