Using Whole-Exome Sequencing to Identify Genetic Markers for Carboplatin and Gemcitabine-Induced Toxicities
Open Access
- 14 January 2016
- journal article
- research article
- Published by American Association for Cancer Research (AACR) in Clinical Cancer Research
- Vol. 22 (2), 366-373
- https://doi.org/10.1158/1078-0432.ccr-15-0964
Abstract
Purpose: Chemotherapies are associated with significant interindividual variability in therapeutic effect and adverse drug reactions. In lung cancer, the use of gemcitabine and carboplatin induces grade 3 or 4 myelosuppression in about a quarter of the patients, while an equal fraction of patients is basically unaffected in terms of myelosuppressive side effects. We therefore set out to identify genetic markers for gemcitabine/carboplatin-induced myelosuppression.Keywords
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This publication has 32 references indexed in Scilit:
- Network enrichment analysis: extension of gene-set enrichment analysis to gene networksBMC Bioinformatics, 2012
- An integrated encyclopedia of DNA elements in the human genomeNature, 2012
- A genome-wide association study identifies four genetic markers for hematological toxicities in cancer patients receiving gemcitabine therapyPharmacogenetics and Genomics, 2012
- A Genome-Wide Association Study of Overall Survival in Pancreatic Cancer Patients Treated with Gemcitabine in CALGB 80303Clinical Cancer Research, 2012
- Gemcitabine metabolic and transporter gene polymorphisms are associated with drug toxicity and efficacy in patients with locally advanced pancreatic cancerCancer, 2010
- Cancer/Testis Antigen CAGE Exerts Negative Regulation on p53 Expression through HDAC2 and Confers Resistance to Anti-cancer DrugsOnline Journal of Public Health Informatics, 2010
- The Cancer/Testis Antigen CAGE with Oncogenic Potential Stimulates Cell Proliferation by Up-regulating Cyclins D1 and E in an AP-1- and E2F-dependent MannerOnline Journal of Public Health Informatics, 2010
- Phase II Studies of Gemcitabine and Cisplatin in Heavily and Minimally Pretreated Metastatic Breast CancerJournal of Clinical Oncology, 2009
- Global networks of functional coupling in eukaryotes from comprehensive data integrationGenome Research, 2009
- Characterizing the expression of the human olfactory receptor gene family using a novel DNA microarrayGenome Biology, 2007