Thiol-inducible direct fluorescence monitoring of drug release
- 1 January 2013
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Organic & Biomolecular Chemistry
- Vol. 11 (4), 580-585
- https://doi.org/10.1039/c2ob26680f
Abstract
A new bifunctional compound NCC, which undergoes thiol-mediated disulfide cleavage after cell entry, produces a red-shifted fluorescent emission in the cytosol and releases free active DNA alkylating agent CLB into the nucleus, and finally leads to DNA damage and cell death.Keywords
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