Endocrine effects of tobacco smoke exposure during lactation in weaned and adult male offspring
Open Access
- 18 April 2013
- journal article
- research article
- Published by Bioscientifica in Journal of Endocrinology
- Vol. 218 (1), 13-24
- https://doi.org/10.1530/joe-13-0003
Abstract
Children from pregnant smokers show more susceptibility to develop obesity in adult life. Previously, we failed to demonstrate a program for obesity in rat offspring only when the mothers were exposed to tobacco smoke during lactation. Here, we studied the short- and long-term effects of smoke exposure (SE) to both dams and their pups during lactation on endocrine and metabolic parameters. For this, we designed an experimental model where nursing rats and their pups were divided into two groups: SE group, exposed to smoke in a cigarette smoking machine (four times/day, from the third to the 21st day of lactation), and group, exposed to filtered air. Pups were killed at 21 and 180 days. At weaning, SE pups showed lower body weight (7%), length (5%), retroperitoneal fat mass (59%), visceral adipocyte area (60%), and higher subcutaneous adipocyte area (95%) with hypoinsulinemia (−29%), hyperthyroxinemia (59%), hypercorticosteronemia (60%), and higher adrenal catecholamine content (+58%). In adulthood, SE offspring showed higher food intake (+10%), body total fat mass (+50%), visceral fat mass (retroperitoneal: 55%; mesenteric: 67%; and epididymal: 55%), and lower subcutaneous adipocyte area (24%) with higher serum glucose (11%), leptin (85%), adiponectin (1.4-fold increase), total triiodothyronine (71%), free thyroxine (57%), TSH (36%), triglycerides (65%), VLDL cholesterol (+66%), and HDL cholesterol (91%) levels and lower corticosteronemia (41%) and adrenal catecholamine content (57%). Our present findings suggest that tobacco SE to both dams and their pups during lactation causes malnutrition in early life that programs for obesity and hormonal and metabolic disturbances in adulthood, only if the pups are submitted to the same smoke environment as the mother.Keywords
This publication has 59 references indexed in Scilit:
- Nicotine induced CpG methylation of Pax6 binding motif in StAR promoter reduces the gene expression and cortisol productionToxicology and Applied Pharmacology, 2011
- Maternal tobacco use modestly alters correlated epigenome-wide placental DNA methylation and gene expressionEpigenetics, 2011
- Adiponectin gene expression and adipocyte diameter: a comparison between epicardial and subcutaneous adipose tissue in menCardiovascular Pathology, 2011
- Prenatal environmental tobacco smoke exposure and early childhood body mass indexPaediatric and Perinatal Epidemiology, 2010
- Environmental tobacco use and indicators of metabolic syndrome in Chinese adultsNicotine & Tobacco Research, 2010
- Thyroid Hormone Levels Associated with Active and Passive Cigarette SmokingThyroid®, 2009
- Prenatal Exposure to Cigarette Smoke Induces Diet- and Sex-Dependent Dyslipidemia and Weight Gain in Adult Murine OffspringEnvironmental Health Perspectives, 2009
- Acute and chronic leptin effect upon in vivo and in vitro rat thyroid iodide uptakeLife Sciences, 2007
- Impact of Smoking and Thiocyanate on Perchlorate and Thyroid Hormone Associations in the 2001–2002 National Health and Nutrition Examination SurveyEnvironmental Health Perspectives, 2007
- Neonatal hyperleptinaemia programmes adrenal medullary function in adult rats: effects on cardiovascular parametersJournal Of Physiology-London, 2007