Mechanisms of Degranulation in Neutrophils
Top Cited Papers
Open Access
- 15 September 2006
- journal article
- Published by Springer Science and Business Media LLC in Allergy, Asthma & Clinical Immunology
- Vol. 2 (3), 98-108
- https://doi.org/10.1186/1710-1492-2-3-98
Abstract
Neutrophils are critical inflammatory cells that cause tissue damage in a range of diseases and disorders. Being bone marrow-derived white blood cells, they migrate from the bloodstream to sites of tissue inflammation in response to chemotactic signals and induce inflammation by undergoing receptor-mediated respiratory burst and degranulation. Degranulation from neutrophils has been implicated as a major causative factor in pulmonary disorders, including severe asphyxic episodes of asthma. However, the mechanisms that control neutrophil degranulation are not well understood. Recent observations indicate that granule release from neutrophils depends on activation of intracellular signalling pathways, including β-arrestins, the Rho guanosine triphosphatase Rac2, soluble NSF attachment protein (SNAP) receptors, the src family of tyrosine kinases, and the tyrosine phosphatase MEG2. Some of these observations suggest that degranulation from neutrophils is selective and depends on nonredundant signalling pathways. This review focuses on new findings from the literature on the mechanisms that control the release of granule-derived mediators from neutrophils.Keywords
This publication has 61 references indexed in Scilit:
- A critical role for vesicle‐associated membrane protein‐7 in exocytosis from human eosinophils and neutrophilsAllergy, 2006
- Induction of Genes Mediating Interferon-dependent Extracellular Trap Formation during Neutrophil DifferentiationOnline Journal of Public Health Informatics, 2004
- Rac2 is critical for neutrophil primary granule exocytosisBlood, 2004
- Neutrophil Extracellular Traps Kill BacteriaScience, 2004
- GTPases and reactive oxygen species: switches for killing and signalingJournal of Cell Science, 2004
- Hematopoietic Cell Regulation by Rac1 and Rac2 Guanosine TriphosphatasesScience, 2003
- Rho GTPases in cell biologyNature, 2002
- Rat Basophilic Leukemia Cells Express Syntaxin-3 and VAMP-7 in Granule MembranesBiochemical and Biophysical Research Communications, 2000
- ARF and PITP restore GTPγS-stimulated protein secretion from cytosol-depleted HL60 cells by promoting PIP2 synthesisCurrent Biology, 1996
- SNAP receptors implicated in vesicle targeting and fusionNature, 1993