Cholinergic Markers in Elderly Patients With Early Signs of Alzheimer Disease
Open Access
- 21 April 1999
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 281 (15), 1401-1406
- https://doi.org/10.1001/jama.281.15.1401
Abstract
A central tenet of Alzheimer disease (AD), established 20 years ago and repeatedly replicated, is the loss of cortical cholinergic markers, specifically, choline acetyltransferase (ChAT) and acetylcholinesterase (AChE) activity, in postmortem tissue from AD patients.1-3 This abnormality has been shown to correlate with neuropathological markers4 and with the severity of dementia.4,5 Therapies designed to reverse the cholinergic deficit, such as AChE inhibitors, are in large measure based on the importance of the cholinergic deficit to cognition and the symptoms of AD.6-8This publication has 11 references indexed in Scilit:
- Cortical cholinergic markers in schizophreniaSchizophrenia Research, 1994
- The Clinical Dementia Rating (CDR)Neurology, 1993
- Behavioral recovery following bilateral lesions of the nucleus basalis does not occur spontaneouslyPharmacology Biochemistry and Behavior, 1986
- Recovery of neocortical choline acetyltransferase activity following ibotenic acid injection into the nucleus basalis of Meynert in ratsBrain Research, 1984
- Choline acetyltransferase activity and histopathology of frontal neocortex from biopsies of demented patientsJournal of the Neurological Sciences, 1982
- A New Clinical Scale for the Staging of DementiaThe British Journal of Psychiatry, 1982
- Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia.BMJ, 1978
- Physostigmine: Improvement of Long-Term Memory Processes in Normal HumansScience, 1978
- NECROPSY EVIDENCE OF CENTRAL CHOLINERGIC DEFICITS IN SENILE DEMENTIAThe Lancet, 1977
- A rapid radiochemical method for the determination of choline acetyltransferaseJournal of Neurochemistry, 1975