Association between proto-oncoprotein Rel and TATA-binding protein mediates transcriptional activation by NF-κB
- 1 September 1993
- journal article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 365 (6445), 412-419
- https://doi.org/10.1038/365412a0
Abstract
The c-Rel protein is able to associate in vitro and in vivo with the TATA-binding protein (TBP) of the TFIID complex. Coexpression of TBP with c-Rel augments transactivation from the kappa B site in Drosophila Schneider cells. DNA-binding mutants of TBP not only fail to cooperate, but they repress transactivation by c-Rel. There may be a direct communication between kappa B enhancer binding proteins and basal transcription factors which leads to enhanced transcription.Keywords
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