Cyproheptadine-Induced Remission of Cushing's Disease
- 30 October 1975
- journal article
- case report
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 293 (18), 893-896
- https://doi.org/10.1056/nejm197510302931802
Abstract
Experimental evidence suggests a Central-nervous-system origin of Cushing's disease and a role for serotonin in the regulation of ACTH release. The efficacy of cyproheptadine therapy, therefore, was studied in three patients with such disease. Administration of 24 mg daily over a period of three to six months was associated with prompt and sustained clinical and laboratory remission. Lessening of the physical manifestations of hypercorticism occurred, together with marked improvement in muscular weakness. Urinary corticosteroid excretion and cortisol secretory rate returned to normal. The urinary corticosteroid response to dexamethasone (2 mg per day) became normal; a paradoxical increase followed 8 mg per day. Abnormal circadian periodicity of plasma cortisol concentrations persisted. Return of normal amounts of Stage III to IV sleep occurred in the one patient so studied, who previously had markedly decreased periods of these stages. Discontinuance of therapy in one patient was associated with return of laboratory evidence of hypercorticism. (N Engl J Med 293:893–896, 1975)Keywords
This publication has 15 references indexed in Scilit:
- A Sensitive Bioassay for the Determination of Human Plasma ACTH LevelsJournal of Clinical Endocrinology & Metabolism, 1975
- Sleep EEG Stages and Plasma Growth Hormone Concentration in States of Endogenous and Exogenous Hypercortisolemia or ACTH ElevationJournal of Clinical Endocrinology & Metabolism, 1974
- Inhibition of Hypoglycemia-Induced Cortisol Secretion by the Serotonin Antagonist CyproheptadineJournal of Clinical Endocrinology & Metabolism, 1974
- Stimulation of Human Prolactin Secretion by Intravenous Infusion of L-TryptophanJCI Insight, 1973
- A Homologous Radioimmunoassay for Human Prolactin1Journal of Clinical Endocrinology & Metabolism, 1973
- Lack of Responsiveness to l -Dopa in Cushing's Disease1Journal of Clinical Endocrinology & Metabolism, 1973
- Growth hormone and cortisol responsiveness in Cushing's syndromeAmerican Journal Of Medicine, 1972
- Therapeutic Possibilities in Cushing's SyndromeNew England Journal of Medicine, 1971
- Biogenic Amines and the States of SleepScience, 1969
- URINARY FREE CORTISOL MEASURED BY COMPETITIVE PROTEIN BINDINGJournal of Endocrinology, 1968