Symptom responses, long‐term outcomes and adverse events beyond 3 years of high‐frequency gastric electrical stimulation for gastroparesis
- 18 November 2005
- journal article
- Published by Wiley in Neurogastroenterology & Motility
- Vol. 18 (1), 18-27
- https://doi.org/10.1111/j.1365-2982.2005.00732.x
Abstract
The aims were to determine symptom responses and long-term outcomes in gastroparetic patients receiving gastric electrical stimulation (GES) therapy beyond 3 years by presenting per protocol analysis and intention-to-treat (ITT) analysis. Data collected at baseline, 1 year and beyond 3 years in 55 patients included total symptom scores (TSS), nutritional status, weight, hospitalizations, the use of prokinetic and/or antiemetic medications, HbA1c in diabetics and adverse events. Of the 55 patients, 10 died of non-pacemaker-related complications, six had the devices removed and two could not be reached. The remaining 37 patients had the device activated for a mean of 45 months. Both per protocol and ITT analysis demonstrated that TSS, hospitalization days and the use of medications were all significantly reduced at 1 year and were sustained beyond 3 years. Average TSS decreased by 62.5% for the 37 patients completing 3 years of GES. At implantation, 15/37 patients required nutritional support and only five continued beyond 3 years. Mean HbA1c level in diabetics was significantly reduced from 9.5 to 7.9% at 3 years. We conclude that a significant improvement in symptoms and all measures of clinical outcome can be maintained for greater than 3 years with GES in patients with refractory gastroparesis.Keywords
This publication has 18 references indexed in Scilit:
- Clinical response to gastric electrical stimulation in patients with postsurgical gastroparesisClinical Gastroenterology and Hepatology, 2004
- Treatment of Diabetic Gastroparesis by High-Frequency Gastric Electrical StimulationDiabetes Care, 2004
- Further experience with gastric stimulation to treat drug refractory gastroparesisThe American Journal of Surgery, 2003
- Gastric electrical stimulation for medically refractory gastroparesisGastroenterology, 2003
- Gastric electrical stimulation for gastroparesis improves nutritional parameters at short, intermediate, and long‐term follow‐upJournal of Parenteral and Enteral Nutrition, 2003
- Gastric Electrical Stimulation in Intractable Symptomatic GastroparesisDigestion, 2002
- Gastric pacing is a new surgical treatment for gastroparesisThe American Journal of Surgery, 2001
- Assessment of gastric emptying using a low fat meal: establishment of international control valuesThe American Journal of Gastroenterology, 2000
- Case Report: Electrical Stimulation at a Frequency Higher than Basal Rate in Human StomachDigestive Diseases and Sciences, 1997
- Repeated measurements: What is measured and what repeats?Statistics in Medicine, 1990