Precipitin tests and ELISA were used to investigate host-feeding patterns of 172 blood-fed Aedes albopictus (Skuse) collected at Potosi, MO, during the summers of 1989 and 1990. One hundred ten (64.0%) mosquitoes had fed on mammals, 29 (16.9%) on birds, and none on turtles or snakes. Thirty-three (19.2%) mosquitoes failed to react in all tests. Eighty-six (78.2%) of the 110 mammalian feeds were positive for lower taxa as follows: rabbit, 24.5%; deer, 14.5%; dog, 13.6%; human, 8.2%; squirrel, 7.3%; opossum, 4.5%; myomorph rodents other than Rattus, 3.6%; raccoon, 0.9%; and bovine, 0.9%. Positive feeds were not detected for the following mammals: cat (n = 99); horse (n = 95); Rattus (n = 84); and swine (n = 84). Fourteen (48.3%) of the 29 avian feeds were positive for lower taxa as follows: Passeriformes, 24.1%; Columbiformes, 17.2%; Ciconiiformes, 3.4%; and quail, 3.4%. These data, the first on host-feeding patterns for Ae. albopictus populations in the New World, indicate that Ae. albopictus is an opportunistic feeder that utilizes a wide variety of hosts and, therefore, has the potential to become involved in the transmission cycles of indigenous arboviruses.