Nitric oxide production during adjuvant‐induced and collagen‐induced arthritis
- 1 October 1996
- journal article
- research article
- Published by Wiley in Arthritis & Rheumatism
- Vol. 39 (10), 1677-1684
- https://doi.org/10.1002/art.1780391010
Abstract
Objective. To investigate the role of nitric oxide (NO) production and NO synthase (NOS) induction during adjuvant‐induced arthritis (AIA) and collagen‐induced arthritis (CIA) in Dark Agouti rats. Methods. Urinary nitrate excretion and immune NOS (iNOS) messenger RNA (mRNA) expression were measured in the joint, lymph node, spleen, and liver tissues following the induction of either AIA or CIA. Results. Urinary nitrate excretion and iNOS mRNA expression increased substantially during joint inflammation in both models of arthritis. However, the increases in urinary nitrate excretion and iNOS mRNA expression observed in the joint, liver, and spleen tissues during AIA were greater than those observed during CIA, although iNOS induction in the lymph nodes was similar for both models. A prior injection with Mycobacterium bovis heat‐shock protein resulted in suppression of arthritis and NO production in AIA, but not in CIA. Conclusion. Differences in NO production during AIA versus CIA are a reflection of the fundamental pathophysiologic differences between these 2 models of arthritis. Thus, NO production in these 2 models could not be merely a nonspecific reaction to the adjuvant injection, nor simply a byproduct of local inflammation in the joint.Keywords
This publication has 38 references indexed in Scilit:
- Nitric oxide and superoxide radical are involved in both initiation and development of adjuvant arthritis in ratsLife Sciences, 1994
- N‐Monomethyl arginine, an inhibitor of nitric oxide synthase, suppresses the development of adjuvant arthritis in ratsArthritis & Rheumatism, 1994
- Induction of autoimmune arthritis in rats by immunization with homologous rat type II collagen is restricted to the RT1av1 haplotypeArthritis & Rheumatism, 1993
- Suppression of adjuvant‐induced arthritis in da rats by incomplete freund's adjuvantArthritis & Rheumatism, 1993
- The effects of flurbiprofen on the passive transfer of adjuvant-induced arthritisInflammation Research, 1992
- Induction of arthritis in rats by aqueous suspensions of mycobacteria without the use of oilArthritis & Rheumatism, 1991
- Histopathology of arthritis induced in rats by active immunization to mycobacterial antigens or by systemic transfer of t lymphocyte lines. a light and electron microscopic study of the articular surface using cationized ferritinArthritis & Rheumatism, 1987
- Synergy between adjuvant arthritis and collagen-induced arthritis in rats.The Journal of Experimental Medicine, 1985
- T Lymphocytes in Collagen II‐Induced Arthritis in MiceScandinavian Journal of Immunology, 1985
- The cellular basis of adjuvant arthritis: II. Characterization of the cells mediating passive transferCellular Immunology, 1983