GilR, an Unusual Lactone‐Forming Enzyme Involved in Gilvocarcin Biosynthesis
- 14 May 2009
- journal article
- research article
- Published by Wiley in ChemBioChem
- Vol. 10 (8), 1305-1308
- https://doi.org/10.1002/cbic.200900130
Abstract
Last at last : The terminal step of the gilvocarcin V (GV) biosynthetic pathway is an unusual lactone formation. Here we show that the enzyme, GilR, dehydrogenates the hemiacetal moiety of pregilvocarcin V to the lactone found in GV by using covalently bound FAD.Keywords
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