Assessment of pulse rate variability by the method of pulse frequency demodulation
Open Access
- 1 November 2005
- journal article
- clinical trial
- Published by Springer Science and Business Media LLC in BioMedical Engineering OnLine
- Vol. 4 (1), 62
- https://doi.org/10.1186/1475-925x-4-62
Abstract
Background Due to its easy applicability, pulse wave has been proposed as a surrogate of electrocardiogram (ECG) for the analysis of heart rate variability (HRV). However, its smoother waveform precludes accurate measurement of pulse-to-pulse interval by fiducial-point algorithms. Here we report a pulse frequency demodulation (PFDM) technique as a method for extracting instantaneous pulse rate function directly from pulse wave signal and its usefulness for assessing pulse rate variability (PRV). Methods Simulated pulse wave signals with known pulse interval functions and actual pulse wave signals obtained from 30 subjects with a trans-dermal pulse wave device were analyzed by PFDM. The results were compared with heart rate and HRV assessed from simultaneously recorded ECG. Results Analysis of simulated data revealed that the PFDM faithfully demodulates source interval function with preserving the frequency characteristics of the function, even when the intervals fluctuate rapidly over a wide range and when the signals include fluctuations in pulse height and baseline. Analysis of actual data revealed that individual means of low and high frequency components of PRV showed good agreement with those of HRV (intraclass correlation coefficient, 0.997 and 0.981, respectively). Conclusion The PFDM of pulse wave signal provides a reliable assessment of PRV. Given the popularity of pulse wave equipments, PFDM may open new ways to the studies of long-term assessment of cardiovascular variability and dynamics.Keywords
This publication has 24 references indexed in Scilit:
- Autonomic responses during inhalation of natural fragrance of “Cedrol” in humansAutonomic Neuroscience, 2003
- Effects of mental and physical demands on heart rate variability during computer workEuropean Journal of Applied Physiology, 2002
- Baroreflex Sensitivity and Heart Rate Variability in the Identification of Patients at Risk for Life-Threatening ArrhythmiasCirculation, 2001
- Heart instantaneous frequency (HIF): an alternative approach to extract heart rate variabilityIEEE Transactions on Biomedical Engineering, 2001
- Complex DemodulationPublished by Wiley ,2000
- Heart rate variability in health and diseaseScandinavian Journal of Work, Environment & Health, 1995
- Reduced heart rate variability and mortality risk in an elderly cohort. The Framingham Heart Study.Circulation, 1994
- Decreased heart rate variability and its association with increased mortality after acute myocardial infarctionThe American Journal of Cardiology, 1987
- Power spectral analysis of heart rate and arterial pressure variabilities as a marker of sympatho-vagal interaction in man and conscious dog.Circulation Research, 1986
- STATISTICAL METHODS FOR ASSESSING AGREEMENT BETWEEN TWO METHODS OF CLINICAL MEASUREMENTThe Lancet, 1986