Enzyme Directed Templating of Artificial Bone Mineral
- 14 January 2009
- journal article
- research article
- Published by Wiley in Advanced Materials
- Vol. 21 (4), 425-430
- https://doi.org/10.1002/adma.200802242
Abstract
An artificial, in vitro biomineralization process that utilizes a nanofiber gel to as a substrate for biomimetic hydroxyapatite mineralization in three dimensions is presented. The system employs the natural enzyme alkaline phosphatase and a phosphorylated, anionic nanofiber gel matrix to template hydroxyapatite nanocrystals with size, shape, and crystallographic orientation resembling natural bone mineral.Keywords
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