Intestinal M Cells: A Pathway for Entry of Reovirus into the Host
- 24 April 1981
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 212 (4493), 471-472
- https://doi.org/10.1126/science.6259737
Abstract
Thirty minutes after inoculation of reovirus type 1 into the intestinal lumen of the mouse, viruses were found adhering to the surface of intestinal M cells but not other epithelial cells. Within 1 hour, viruses were seen in the M cell cytoplasm and were associated with mononuclear cells in the intercellular space adjacent to the M cell. These findings suggest that M cells are the site where reovirus penetrates the intestinal epithelium.This publication has 15 references indexed in Scilit:
- Molecular basis of reovirus virulence. Role of the M2 gene.The Journal of Experimental Medicine, 1980
- Genetics of reovirus: Identification of the ds RNA segments encoding the polypeptides of the μ and σ size classesVirology, 1978
- The rotavirusesArchiv für die gesamte Virusforschung, 1978
- THE ROUTE OF ENTERIC INFECTION IN NORMAL MICEThe Journal of Experimental Medicine, 1974
- Pinocytosis by epithelium associated with lymphoid follicles in the bursa of fabricius, appendix, and Peyer's patches. An electron microscopic studyJournal of Anatomy, 1973
- Uptake of adenovirus by intestinal absorptive cells of the suckling rat. I. The Neonatal IleumThe Anatomical Record, 1973
- Studies on Infection and Immunity in Experimental Typhoid Fever: VII. The Distribution of Salmonella typhi in Chimpanzee Tissue Following Oral Challenge, and the Relationship Between the Numbers of Bacilli and Morphologic LesionsThe Journal of Infectious Diseases, 1968
- The Ingestion of Proteins and Colloidal Materials by Columnar Absorptive Cells of the Small Intestine in Suckling Rats and MiceThe Journal of cell biology, 1959
- Emerging Concept of Poliomyelitis InfectionScience, 1955
- The absorption of antibodies from immune sera by the gut of the young ratProceedings of the Royal Society of London. Series B - Biological Sciences, 1955