Memory disorders in probable Alzheimer's disease: the role of hippocampal atrophy as shown with MRI.
Open Access
- 1 May 1995
- journal article
- research article
- Published by BMJ in Journal of Neurology, Neurosurgery & Psychiatry
- Vol. 58 (5), 590-597
- https://doi.org/10.1136/jnnp.58.5.590
Abstract
Magnetic resonance based volumetric measures of hippocampal formation, amygdala (A), caudate nucleus (CN), normalised for total intracranial volume (TIV), were analysed in relation to measures of cognitive deterioration and specific features of memory functions in 18 patients with probable Alzheimer's disease. Neuropsychological examination included the mini mental state examination (MMSE), the Mattis dementia rating scale (DRS), tests of executive functions, assessment of language abilities and praxis, the Wechsler memory scale (WMS), the California verbal learning test (CVLT) and the Grober and Buschke test. The volume of the hippocampal formation (HF/TIV) was correlated with specific memory variables: memory quotient and paired associates of the WMS; intrusions and discriminability at recognition for the Grober and Buschke test. By contrast, except for intrusions, no correlations were found between memory variables and the volume of amygdala (A/TIV). No correlations were found between the volume of caudate nuclei (CN/TIV) and any neuropsychological score. The volume of the hippocampal formation was therefore selectively related to quantitative and qualitative aspects of memory performance in patients with probable Alzheimer's disease.Keywords
This publication has 34 references indexed in Scilit:
- MR‐based hippocampal volumetry in the diagnosis of Alzheimer's diseaseNeurology, 1992
- Memory and the hippocampus: A synthesis from findings with rats, monkeys, and humans.Psychological Review, 1992
- Are all subcortical dementias Alike?: Verbal learning and memory in Parkinson's and huntington's disease patientsJournal of Clinical and Experimental Neuropsychology, 1990
- Regeneration of sensory hair cells in the vertebrate inner earTrends in Neurosciences, 1988
- Genuine memory deficits in dementiaDevelopmental Neuropsychology, 1987
- Implicit and explicit memory for new associations in normal and amnesic subjects.Journal of Experimental Psychology: Learning, Memory, and Cognition, 1985
- Clinical diagnosis of Alzheimer's diseaseNeurology, 1984
- A New Depression Scale Designed to be Sensitive to ChangeThe British Journal of Psychiatry, 1979
- The role of the association in recognition memory.Journal of Experimental Psychology, 1974
- LOSS OF RECENT MEMORY AFTER BILATERAL HIPPOCAMPAL LESIONSJournal of Neurology, Neurosurgery & Psychiatry, 1957