Brain alkaline intracellular pH after neonatal encephalopathy
- 12 November 2002
- journal article
- research article
- Published by Wiley in Annals of Neurology
- Vol. 52 (6), 732-742
- https://doi.org/10.1002/ana.10365
Abstract
Experimental studies demonstrate an alkaline shift in brain intracellular pH (pHi) after hypoxia-ischemia (HI). In infants with neonatal encephalopathy after HI, our aims were to assess (1) brain pHi during the first 2 weeks after birth in infants categorized according to magnetic resonance imaging (MRI) during the first 2 weeks after birth and at more than 3 months of age, and neurodevelopmental outcome at 1 year; (2) the relationship between brain pHi and lactate/creatine; and (3) duration of alkaline brain pHi. Seventy-eight term infants with neonatal encephalopathy were studied using MR techniques. One hundred and fifty-one studies were performed throughout the first year including 56 studies of 50 infants during the first 2 weeks after birth. pHi was calculated using phosphorus-31 MR spectroscopy and lactate/creatine was measured using proton MRS. The mean (standard deviation [SD]) brain pHi during the first 2 weeks after birth in infants with severely abnormal versus normal MRI was 7.24 (SD, 0.17) versus 7.04 (SD, 0.05; p < 0.001); in infants who subsequently developed cerebral atrophy versus those who did not: 7.23 (SD, 0.17) versus 7.06 (SD, 0.06; p < 0.05); in infants who died or had a severe neurodevelopmental impairment versus normal outcome: 7.28 (SD, 0.15) versus 7.11 (SD, 0.09; p < 0.05). Brain alkalosis was associated with increased brain lactate/creatine (p < 0.001). pHi remained more alkaline in the severe outcome group up to 20 weeks after birth (p < 0.05). Ann Neurol 2002;52:000–000This publication has 79 references indexed in Scilit:
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