Hepatitis B reverse seroconversion in HIV-positive patients: case series and review of the literature
- 30 March 2007
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in AIDS
- Vol. 21 (6), 771-774
- https://doi.org/10.1097/qad.0b013e3280ad47f5
Abstract
Hepatitis B (HBV) reverse seroconversion is rare in HIV disease but can be fatal. We present a case series of 6 patients with reverse seroconversion and review 18 additional cases described in the literature. Elevated transaminases were seen in 13/21 (62%). Reverse seroconversion occurred more frequently in the setting of HIV virologic failure. Only 3 patients demonstrated reverse seroconversion in the setting of lamivudine or tenofovir withdrawal. 2/24 (8%) patients died from their HBV flare.Keywords
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