A genetic analysis of therudimentarylocus ofDrosophila melanogaster
- 1 February 1971
- journal article
- research article
- Published by Hindawi Limited in Genetics Research
- Vol. 17 (1), 53-81
- https://doi.org/10.1017/s0016672300012039
Abstract
SUMMARY: A study of the structural and functional organization of therudimentary(r: 1–54·5) locus ofDrosophila melanogasterhas demonstrated that alleles of this gene reside in a number of recombinationally separable sites, and display a complex pattern of interallelic interaction. Data relating to interallelic interaction have been utilized to construct a linear complementation map consisting of 7 complementation units and 16 complementation groups. Comparison of the genetic fine structure map and the complementation map shows that the two maps are approximately co-linear. Totally non-complementing alleles reside at both ends of the fine structure map. Therlocus is best interpreted by the model of a single cistron whose product affects several distinct developmental processes and whose alleles display a complex pattern of interallelic complementation. Intragenic recombination within therlocus is accompanied by the appearance of parental and recombinant flanking marker classes not expected on the basis of reciprocal recombination. Studies with half-tetrads demonstrate that intragenic recombination can occur either by gene conversion or by a reciprocal exchange mechanism. The pattern of organization seen at therlocus is similar to patterns of organization found in work with fungal genes.Keywords
This publication has 15 references indexed in Scilit:
- THE MECHANISM OF GENETIC RECOMBINATIONBiological Reviews, 1970
- The interpretation of complementation dataGenetics Research, 1966
- The analysis of genetic recombination on the polaron hybrid DNA modelGenetics Research, 1965
- A mechanism for gene conversion in fungiGenetics Research, 1964
- Genetic Controls of Allelic Recombination in NeurosporaNature, 1964
- A Theory of Crossing-Over by Means of Hybrid Deoxyribonucleic AcidNature, 1963
- Complementation Among the Sub-Genic Mutants in the r-Locus of Drosophila MelanogasterNature, 1959
- Studies on female-sterility genes inDrosophila melanogasterMolecular Genetics and Genomics, 1956
- The Infertility of Rudimentary Winged Females of Drosophila ampelophilaThe American Naturalist, 1915
- A modification of the sex ratio, and of other ratios, inDrosophila through linkageMolecular Genetics and Genomics, 1912