The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappa B that blocks TNFalpha -induced apoptosis
- 15 February 1999
- journal article
- Published by Cold Spring Harbor Laboratory in Genes & Development
- Vol. 13 (4), 382-387
- https://doi.org/10.1101/gad.13.4.382
Abstract
Bcl-2-family proteins are key regulators of the apoptotic response. Here, we demonstrate that the pro-survival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-κB. We show that bfl-1 gene expression is dependent on NF-κB activity and that it can substitute for NF-κB to suppress TNFα-induced apoptosis. bfl-1 promoter analysis identified an NF-κB site responsible for its Rel/NF-κB-dependent induction. The expression of bfl-1 in immune tissues supports the protective role of NF-κB in the immune system. The activation of Bfl-1 may be the means by which NF-κB functions in oncogenesis and promotes cell resistance to anti-cancer therapy.Keywords
This publication has 37 references indexed in Scilit:
- Rel blocks both anti-Fas- and TNFα-induced apoptosis and an intact Rel transactivation domain is essential for this effectCell Death & Differentiation, 1998
- NF-κB Antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to Suppress Caspase-8 ActivationScience, 1998
- The Bcl-2 Protein Family: Arbiters of Cell SurvivalScience, 1998
- Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell DeathCell, 1996
- Suppression of TNF-α-Induced Apoptosis by NF-κBScience, 1996
- TNF- and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-κBScience, 1996
- An Essential Role for NF-κB in Preventing TNF-α-Induced Cell DeathScience, 1996
- Inhibition of NF-kappaB/Rel induces apoptosis of murine B cells.1996
- Cloning of human Bcl-2 homologue: inflammatory cytokines induce human A1 in cultured endothelial cellsBlood, 1996
- A1, a Bcl-2 family member, prolongs cell survival and permits myeloid differentiationBlood, 1996