Sudoriferous acrosyringeal acantholytic disease. A subset of Graver's disease
- 1 April 1996
- journal article
- Published by Wiley in Journal of Cutaneous Pathology
- Vol. 23 (2), 151-164
- https://doi.org/10.1111/j.1600-0560.1996.tb01289.x
Abstract
Three selected cases of transient acantholytic dermatosis were studied because of their definitive correlation with sweating due to fever and/ or bed-ridden situations. Biopsy specimens were serially sectioned and acantholysis was found in the acrosyringium or traced to connect to the acrosyringium in all biopsy specimens. Carcinoembryonic antigen (CEA) and eccrine gland-specific monoclonal antibody, IKH-4, were positive in acantholytic cells. Electron microscopy revealed electron dense material filling the lumen of intraepidermal eccrine ducts. This material leaked into lateral intercellular spaces of the luminal cells, passing tight junctions. Marked edema and numerous lysosomes were reminiscent of those found when eccrine acrosyringium is formed in the embryo; this suggested that an occluded and damaged eccrine intraepidermal duct was being rebuilt via lysosomal digestion.Keywords
This publication has 17 references indexed in Scilit:
- The Dependence of Detergent-Induced Cell Dissociation in Non-Palmo-Plantar Stratum Corneum on Endogenous ProteolysisJournal of Investigative Dermatology, 1990
- Evidence that Cell Shedding from Plantar Stratum Corneum In Vitro Involves Endogenous Proteolysis of the Desmosomal Protein Desmoglein IJournal of Investigative Dermatology, 1990
- Transient acantholytic dermatosis in immunocompromised febrile patients with cancerArchives of Dermatology, 1987
- Transient acantholytic dermatosis (Grover's disease). A skin disorder related to heat and sweatingArchives of Dermatology, 1985
- Transient acantholytic dermatosis: a reevaluationArchives of Dermatology, 1977
- Benign papular acantholytic dermatosisArchives of Dermatology, 1976
- Focal acantholytic dyskeratosisArchives of Dermatology, 1972
- Transient acantholytic dermatosisArchives of Dermatology, 1970
- Mechanisms of Blister FormationArchives of Dermatology, 1957
- Disruption of Tonofibrils and Intercellular Bridges by Disulfide-Splitting Agents1Journal of Investigative Dermatology, 1956