Nanomedicines: addressing the scientific and regulatory gap
Top Cited Papers
- 27 March 2014
- journal article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 1313 (1), 35-56
- https://doi.org/10.1111/nyas.12403
Abstract
Nanomedicine is the application of nanotechnology to the discipline of medicine: the use of nanoscale materials for the diagnosis, monitoring, control, prevention, and treatment of disease. Nanomedicine holds tremendous promise to revolutionize medicine across disciplines and specialties, but this promise has yet to be fully realized. Beyond the typical complications associated with drug development, the fundamentally different and novel physical and chemical properties of some nanomaterials compared to materials on a larger scale (i.e., their bulk counterparts) can create a unique set of opportunities as well as safety concerns, which have only begun to be explored. As the research community continues to investigate nanomedicines, their efficacy, and the associated safety issues, it is critical to work to close the scientific and regulatory gaps to assure that nanomedicine drives the next generation of biomedical innovation.Keywords
This publication has 29 references indexed in Scilit:
- The therapeutic equivalence of complex drugsRegulatory Toxicology and Pharmacology, 2011
- Phase I and Pharmacokinetic Studies of CYT-6091, a Novel PEGylated Colloidal Gold-rhTNF NanomedicineClinical Cancer Research, 2010
- Polymeric drugs for efficient tumor-targeted drug delivery based on EPR-effectEuropean Journal of Pharmaceutics and Biopharmaceutics, 2009
- Protein nanoparticles as drug carriers in clinical medicineAdvanced Drug Delivery Reviews, 2008
- Direct evidence for rapid and selective induction of tumor neovascular permeability by tumor necrosis factor and a novel derivative, colloidal gold bound tumor necrosis factorInternational Journal of Cancer, 2007
- Colloidal Gold: A Novel Nanoparticle Vector for Tumor Directed Drug DeliveryDrug Delivery, 2004
- Pharmacokinetics of Pegylated Liposomal DoxorubicinClinical Pharmacokinetics, 2003
- Liposome application: problems and prospectsCurrent Opinion in Colloid & Interface Science, 2001
- Transmembrane ammonium sulfate gradients in liposomes produce efficient and stable entrapment of amphipathic weak basesBiochimica et Biophysica Acta (BBA) - Biomembranes, 1993
- Gelation of liposome interior A novel method for drug encapsulationFEBS Letters, 1992