Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA
- 1 July 1988
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 334 (6180), 320-325
- https://doi.org/10.1038/334320a0
Abstract
Poliovirus RNA is naturally uncapped, therefore its translation must proceed via a cap-independent mechanism. Translation initiation on poliovirus RNA occurs by binding of ribosomes to an internal sequence within the 5′ noncoding region. This novel mechanism of initiation may explain the disparate translation of several other eukaryotic messenger RNAs.Keywords
This publication has 48 references indexed in Scilit:
- Bifunctional messenger RNAs in eukaryotesCell, 1986
- Multiple upstream AUG codons mediate translational control of GCN4Cell, 1986
- Translational and transcriptional control elements in the untranslated leader of the heat-shock gene hsp22Cell, 1986
- Initiation of translation at internal AUG codons in mammalian cellsNature, 1984
- Functional characterization of eukaryotic mRNA cap binding protein complex: effects on translation of capped and naturally uncapped RNAsBiochemistry, 1984
- Complete nucleotide sequences of all three poliovirus serotype genomesJournal of Molecular Biology, 1984
- Primary structure, gene organization and polypeptide expression of poliovirus RNANature, 1981
- Binding of Ribosomes to Linear and Circular Forms of the 5′‐Terminal Leader Fragment of Tobacco‐Mosaic‐Virus RNAEuropean Journal of Biochemistry, 1981
- An enzymatic activity in uninfected cells that cleaves the linkage between poliovirion RNA and the 5′ terminal proteinCell, 1978
- An Efficient mRNA‐Dependent Translation System from Reticulocyte LysatesEuropean Journal of Biochemistry, 1976