Survival After a Psychoeducational Intervention for Patients With Cutaneous Malignant Melanoma: A Replication Study
- 20 December 2007
- journal article
- research article
- Published by American Society of Clinical Oncology (ASCO) in Journal of Clinical Oncology
- Vol. 25 (36), 5698-5703
- https://doi.org/10.1200/jco.2007.10.8894
Abstract
Purpose: The results of a randomized, intervention study done in 1993 of psychoeducation for patients with early-stage malignant melanoma showed a beneficial effect on recurrence and survival 6 years after the intervention. In the present study, we replicated the study with 258 Danish patients with malignant melanoma. We also compared recurrence and survival among the participants in the randomized study with 137 patients who refused to participate.Patients and Methods: We randomly assigned 262 patients with primary malignant melanoma to a control or an intervention group. Patients in the intervention group were offered six weekly 2-hour sessions of psychoeducation. Participants and nonparticipants were followed up for vital status and recurrence 4 to 6 years after surgical treatment. Prognostic factors (thickness of the tumor and lymph node status), sex, and age were adjusted for in a Cox regression model (proportional hazards regression) to derive an adjusted survival rate ratio and an adjusted relapse-free survival rate ratio, with 95% CIs.Results: The hazard ratio was 1.30 (95% CI, 0.5 to 3.5) for survival and 0.73 (95% CI, 0.3 to 1.9) for recurrence. Being a nonparticipant increased the risk for death by more than two-fold (hazard ratio, 2.26; 95% CI, 1.0 to 5.2) over that of participants.Conclusion: Psychoeducation did not increase survival or the recurrence-free interval among patients with malignant melanoma; however, nonparticipants had a statistically significantly greater risk for death than participants.Keywords
This publication has 26 references indexed in Scilit:
- Impact of socio-economic deprivation on death rates after surgery for upper gastrointestinal tract cancerBritish Journal of Cancer, 2006
- Socio-economic factors and breast cancer survival – a population-based cohort study (Sweden)Cancer Causes & Control, 2005
- Psychoeducational Intervention for Patients With Cutaneous Malignant Melanoma: A Replication StudyJournal of Clinical Oncology, 2005
- Personality and disease outcome in malignant melanomaJournal of Psychosomatic Research, 2005
- Health-Related Quality of Life Parameters As Prognostic Factors in a Nonmetastatic Breast Cancer Population: An International Multicenter StudyJournal of Clinical Oncology, 2004
- Immune function and adjustment style: Do they predict survival in breast cancer?Psycho‐Oncology, 2003
- The Effect of Group Psychosocial Support on Survival in Metastatic Breast CancerNew England Journal of Medicine, 2001
- Barriers to Participation in Randomised Controlled TrialsJournal of Clinical Epidemiology, 1999
- A structured psychoeducational intervention for cancer patientsGeneral Hospital Psychiatry, 1994
- EFFECT OF PSYCHOSOCIAL TREATMENT ON SURVIVAL OF PATIENTS WITH METASTATIC BREAST CANCERThe Lancet, 1989