Shedding light on the cell biology of extracellular vesicles
Top Cited Papers
- 17 January 2018
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Reviews Molecular Cell Biology
- Vol. 19 (4), 213-228
- https://doi.org/10.1038/nrm.2017.125
Abstract
Extracellular vesicles are a heterogeneous group of cell-derived membranous structures comprising exosomes and microvesicles, which originate from the endosomal system or which are shed from the plasma membrane, respectively. They are present in biological fluids and are involved in multiple physiological and pathological processes. Extracellular vesicles are now considered as an additional mechanism for intercellular communication, allowing cells to exchange proteins, lipids and genetic material. Knowledge of the cellular processes that govern extracellular vesicle biology is essential to shed light on the physiological and pathological functions of these vesicles as well as on clinical applications involving their use and/or analysis. However, in this expanding field, much remains unknown regarding the origin, biogenesis, secretion, targeting and fate of these vesicles.Keywords
This publication has 192 references indexed in Scilit:
- Genetically Engineered Microvesicles Carrying Suicide mRNA/Protein Inhibit Schwannoma Tumor GrowthMolecular Therapy, 2013
- miR-1289 and “Zipcode”-like Sequence Enrich mRNAs in MicrovesiclesMolecular Therapy Nucleic Acids, 2012
- The P4-ATPase TAT-5 Inhibits the Budding of Extracellular Vesicles in C. elegans EmbryosCurrent Biology, 2011
- The Tetraspanin CD63 Regulates ESCRT-Independent and -Dependent Endosomal Sorting during MelanogenesisDevelopmental Cell, 2011
- ARF6-Regulated Shedding of Tumor Cell-Derived Plasma Membrane MicrovesiclesCurrent Biology, 2009
- Acid sphingomyelinase activity triggers microparticle release from glial cellsThe EMBO Journal, 2009
- The role of integrin binding sites in fibronectin matrix assembly in vivoCurrent Opinion in Cell Biology, 2008
- ESCRT complexes and the biogenesis of multivesicular bodiesCurrent Opinion in Cell Biology, 2008
- Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cellsNature, 2007
- bicoid RNA localization requires specific binding of an endosomal sorting complexNature, 2007