Isosakuranetin-5-O-rutinoside: A New Flavanone with Antidepressant Activity Isolated from Salvia elegans Vahl.
Open Access
- 25 October 2013
- Vol. 18 (11), 13260-13270
- https://doi.org/10.3390/molecules181113260
Abstract
Ursolic acid (1) and a new flavanone, 5-O-(6-rhamnosylglucoside)-7-hydroxy-4'-methoxyflavanone (2), were isolated from the leaves of Salvia elegans Vahl. These natural products displayed antidepressant activity in mice as determined by means of a forced swimming test (FST) evaluation. Structural elucidation was carried out by chemical derivatization (acetylation) and spectroscopic analyses, such as 1H- and 13C-NMR and two-dimensional (2-D) COSY, heteronuclear multiple quantum coherence (HMQC), and heteronuclear multiple-bond correlation (HMBC) spectroscopy experiments.This publication has 18 references indexed in Scilit:
- Towards the study of functional brain development in depression: An Interactive Specialization approachNeurobiology of Disease, 2013
- Structure of Salvioccidentalin, a Diterpenoid with a Rearranged neo-Clerodane Skeleton from Salvia occidentalisMolecules, 2011
- Antidepressant and anxiolytic effects of hydroalcoholic extract from Salvia elegansJournal of Ethnopharmacology, 2006
- The hydroalcoholic extract of Salvia elegans induces anxiolytic- and antidepressant-like effects in ratsJournal of Ethnopharmacology, 2006
- Bioactive Triterpenoids from Salvia SpeciesJournal of Natural Products, 2006
- Abietane Diterpenoids from the Roots of some MexicanSalvia Species (Labiatae): Chemical Diversity, Phytogeographical Significance, and Cytotoxic ActivityChemistry & Biodiversity, 2005
- Antimycotic Spirostanol Saponins from Solanum hispidum Leaves and Their Structure−Activity RelationshipsJournal of Natural Products, 2004
- Flavanones from Cyclotrichium niveumPhytochemistry, 1989
- Flavonoids from Salvia nicolsonianaJournal of Natural Products, 1986
- Strukturaufklärung und Synthese des Didymins, eines Isosakuranetin −7‐β‐rutinosids aus Monarda didyma L.European Journal of Inorganic Chemistry, 1968