Thrombolysis Guided by Perfusion Imaging up to 9 Hours after Onset of Stroke
Top Cited Papers
- 9 May 2019
- journal article
- research article
- Published by Massachusetts Medical Society in The New England Journal of Medicine
- Vol. 380 (19), 1795-1803
- https://doi.org/10.1056/nejmoa1813046
Abstract
The time to initiate intravenous thrombolysis for acute ischemic stroke is generally limited to within 4.5 hours after the onset of symptoms. Some trials have suggested that the treatment window may be extended in patients who are shown to have ischemic but not yet infarcted brain tissue on imaging.Keywords
Funding Information
- National Health and Medical Research Council
- Commonwealth Scientific and Industrial Research Organisation
This publication has 23 references indexed in Scilit:
- Are Titania Photocatalysts and Titanium Implants Safe? Review on the Toxicity of Titanium CompoundsNanomaterials, 2020
- Apparent Diffusion Coefficient Threshold for Delineation of Ischemic CoreInternational Journal of Stroke, 2013
- A Multicentre, Randomized, Double-Blinded, Placebo-Controlled Phase III Study to Investigate Extending the Time for Thrombolysis in Emergency Neurological Deficits (EXTEND)International Journal of Stroke, 2011
- Cerebral Blood Flow Is the Optimal CT Perfusion Parameter for Assessing Infarct CoreStroke, 2011
- Maps of Time to Maximum and Time to Peak for Mismatch Definition in Clinical Stroke Studies Validated With Positron Emission TomographyStroke, 2010
- Optimal Tmax Threshold for Predicting Penumbral Tissue in Acute StrokeStroke, 2009
- Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trialThe Lancet Neurology, 2008
- Thrombolysis with alteplase for acute ischaemic stroke in the Safe Implementation of Thrombolysis in Stroke-Monitoring Study (SITS-MOST): an observational studyThe Lancet, 2007
- Magnetic resonance imaging profiles predict clinical response to early reperfusion: The diffusion and perfusion imaging evaluation for understanding stroke evolution (DEFUSE) studyAnnals of Neurology, 2006
- Hypoxic tissue in ischaemic stroke: persistence and clinical consequences of spontaneous survivalBrain, 2004