The Epidemiology of Inflammatory Bowel Disease in Canada: A Population-Based Study
- 1 July 2006
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in The American Journal of Gastroenterology
- Vol. 101 (7), 1559-1568
- https://doi.org/10.1111/j.1572-0241.2006.00603.x
Abstract
Previously, we have demonstrated a high incidence and prevalence of Crohn's disease (CD) and ulcerative colitis (UC) in the Canadian province of Manitoba. However, the epidemiology of inflammatory bowel disease (IBD) in other regions of Canada has not been defined. The aim of this study was to estimate the incidence and prevalence of CD and UC in diverse regions of Canada and the overall burden of IBD in Canada. We applied a common case identification algorithm, previously validated in Manitoba to the provincial health databases in British Columbia (BC), Alberta (AB), Saskatchewan (SK), Manitoba (MB), and Nova Scotia (NS) to determine the age-adjusted incidence rates per 100,000 person-years for 1998-2000 and prevalence per 100,000 for mid 2000 and to estimate the IBD burden in Canada. Poisson regression was used to assess differences in incidence rates and prevalence by gender, age, and province. The incidence rate for CD ranged from 8.8 (BC) to 20.2 (NS), and for UC ranged from 9.9 (BC) to 19.5 (NS). The prevalence of CD was approximately 15- to 20-fold higher than the incidence rate, ranging from 161 (BC) to 319 (NS). This was similar for the prevalence of UC, which ranged from 162 (BC) to 249 (MB). Adjusting for age and province, the female:male ratio for incidence ratio was 1.31 (p < 0.0001) for CD and 1.02 (n.s.) for UC and was mostly stable across the five provinces. Approximately 0.5% of the Canadian population has IBD. Canada has the highest incidence and prevalence of CD yet reported.Keywords
This publication has 47 references indexed in Scilit:
- The Clustering of Other Chronic Inflammatory Diseases in Inflammatory Bowel Disease: A Population-Based StudyGastroenterology, 2005
- Ulcerative colitis in Olmsted County, Minnesota, 1940-1993: incidence, prevalence, and survivalGut, 2000
- Incidence of Crohn's Disease in Four Counties in Southeastern Norway, 1990–93 A Prospective Population-Based StudyScandinavian Journal of Gastroenterology, 1996
- Ulcerative Colitis in Zagreb, Yugoslavia: Incidence and Prevalence 1980–1989International Journal of Epidemiology, 1991
- Inflammatory Bowel Disease in Indian Migrants in FijiDigestion, 1991
- Incidence of Crohn's disease in Cardiff between 1934-1977.Gut, 1979
- CHANGING PATTERNS IN EPIDEMIOLOGY OF CROHN'S DISEASEThe Lancet, 1974
- Clinical Features and Epidemiological Data on Crohn's Disease in the Basle AreaScandinavian Journal of Gastroenterology, 1971
- An epidemiological study of ulcerative colitis and regional enteritis in the Oxford area.Gut, 1965
- A Study of Ulcerative Colitis in New Zealand, Showing a Low Incidence in MaorisBMJ, 1962